Vilsmeier Reagent
Vilsmeier Reagent is a stable, free-flowing crystalline solid prepared from dimethylformamide (DMF) and carbonyl dichloride (phosgene). It is available in several grades depending on the customer’s requirements. The use of VanDeMark’s pre-formed Vilsmeier Reagent eliminates the need of the user to handle highly toxic phosgene, thionyl chloride, phosphoryl chloride or oxalyl chloride to generate a reagent.
Vilsmeier Reagent has been found to be useful in dehydration, chlorination, and formylation reactions. VanDeMark’s Vilsmeier Reagent is one of the purest that can be produced, reducing by-product formulation in reactions and simplifying workup. The overall utility of Vilsmeier Reagents in effecting chemical transformations can be found in the references cited in the product bulletin (download below). The effectiveness of the (chloromethylene) dimethylammonium chloride in any specific reaction in which a Vilsmeier Reagent is used must be determined beforehand, as its reactivity can vary.
Contact us for the following documentation:- MSDS